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titleboxSARAH TISHKOFF titlebox

professor pictureAssociate Professor

email:tishkoff@umd.edu
phone:
301.405.6038 (office)
301.405.8737 (lab)
301.405.8717
fax:301.314.9358
office:4231 Bio-Psych
graduate programs: Biology, BEES
bullet visit lab page   bullet most recent publications


RESEARCH INTERESTS

We are interested in examining levels and patterns of genetic variation at the genome level among modern humans and non-human primates in order to elucidate the evolutionary forces (mutation, gene conversion, migration, drift, selection) that shape and maintain genetic variation in contemporary populations. These data are being used to reconstruct historical demographic and population differentiation events (including population expansion and contraction, subdivision, and migration) and to test hypotheses of modern human origins, including the possibility of introgression of archaic and modern human genomes.

Recent Publications


Tishkoff SA, Gonder MK, Henn BM, Mortensen H, Knight A, Gignoux C, Fernandopulle N, Lema G, Nyambo TB, Ramakrishnan U, Reed FA, Mountain JL. History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation. Mol Biol Evol. 2007 Oct;24(10):2180-95. Epub 2007 Jul 26.

Gonder MK, Mortensen HM, Reed FA, de Sousa A, Tishkoff SA. Whole-mtDNA genome sequence analysis of ancient African lineages. Mol Biol Evol. 2007 Mar;24(3):757-68. Epub 2006 Dec 28.

Shimada MK, Panchapakesan K, Tishkoff SA, Nato AQ Jr, Hey J. Divergent haplotypes and human history as revealed in a worldwide survey of X-linked DNA sequence variation. Mol Biol Evol. 2007 Mar;24(3):687-98. Epub 2006 Dec 14.

Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet. 2007 Jan;39(1):31-40. Epub 2006 Dec 10.

Reed FA, Tishkoff SA. African human diversity, origins and migrations. Curr Opin Genet Dev. 2006 Dec;16(6):597-605. Epub 2006 Oct 23. Review.

Lind JM, Hutcheson-Dilks HB, Williams SM, Moore JH, Essex M, Ruiz-Pesini E, Wallace DC, Tishkoff SA, O'Brien SJ, Smith MW. Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet. 2007 Jan;120(5):713-22. Epub 2006 Sep 28.

Verrelli BC, Tishkoff SA, Stone AC, Touchman JW. Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzees. Mol Biol Evol. 2006 Aug;23(8):1592-601. Epub 2006 Jun 2.

Awomoyi A, Sirugo G, Newport MJ, Tishkoff S. Global distribution of a novel trinucleotide microsatellite polymorphism (ATA)n in intron 8 of the SLC11A1 gene and susceptibility to pulmonary tuberculosis. Int J Immunogenet. 2006 Feb;33(1):11-5.

Reed FA, Tishkoff SA. Positive selection can create false hotspots of recombination. Genetics. 2006 Mar;172(3):2011-4. Epub 2005 Dec 30.

Wang J, Song L, Gonder MK, Azrak S, Ray DA, Batzer MA, Tishkoff SA, Liang P. Whole genome computational comparative genomics: A fruitful approach for ascertaining Alu insertion polymorphisms. Gene. 2006 Jan 3;365:11-20. Epub 2006 Jan 10.